Freeman is widely credited with inventing the "inverted detective story," a format in which the criminal and the methods of the crime are revealed to the reader at the start, and the suspense lies in watching the detective unravel the case. His first inverted tale, "The Case of Oscar Brodski," appeared in The Singing Bone (1912).
His major works include The Red Thumb Mark (1907), which introduced Dr. Thorndyke; The Eye of Osiris (1911); The Mystery of 31 New Inn (1912); A Silent Witness (1914); The D'Arblay Mystery (1926); Mr. Pottermack's Oversight (1930); and The Jacob Street Mystery (1942). Praised for rigorous plotting and authentic forensic detail, Freeman strongly influenced the Golden Age of detective fiction and later writers such as Dorothy L. Sayers.