His breakthrough came with "Peg Woffington" (1853), adapted from his own play "Masks and Faces," followed by "Christie Johnstone" (1853). His reformist novel "It Is Never Too Late to Mend" (1856), exposing brutality in prisons and Australian goldfields, achieved enormous popularity. "Hard Cash" (1863) attacked abuses in private lunatic asylums, while "Griffith Gaunt" (1866) and "Put Yourself in His Place" (1870), dealing with trade union violence, further established his reputation. "Foul Play" (1868), co-written with Dion Boucicault, influenced reforms in maritime practices.
Reade's masterpiece, "The Cloister and the Hearth" (1861), a historical novel depicting the parents of Erasmus, is widely regarded as one of the finest historical romances in English literature. He died in London in 1884.