Kerouac developed a distinctive "spontaneous prose" style, inspired by jazz improvisation, Buddhist philosophy, and stream-of-consciousness techniques. His breakthrough novel, On the Road (1957), drawn from his cross-country journeys with Neal Cassady, captured the restless spirit of postwar America and became the defining text of Beat culture. Other significant works include The Dharma Bums (1958), exploring Buddhism and wilderness; The Subterraneans (1958); Doctor Sax (1959), based on his childhood; Big Sur (1962), chronicling his struggle with fame and alcoholism; and Desolation Angels (1965).
Despite his literary influence, Kerouac battled alcoholism and withdrew into conservatism and Catholic mysticism in his later years. He died in St. Petersburg, Florida, at age 47. His celebration of freedom, spiritual searching, and spontaneous creativity continues to inspire generations of writers and readers worldwide.