Her masterpiece, East Lynne (1861), became one of the best-selling novels of the nineteenth century. This sensational tale of adultery, mistaken identity, and murder captivated readers with its melodramatic plot and emotional intensity. Other notable works include The Channings (1862), Mrs. Halliburton's Troubles (1862), The Shadow of Ashlydyat (1863), Verner's Pride (1863), St. Martin's Eve (1866), and Roland Yorke (1869). She also wrote widely admired short stories under the pseudonym Johnny Ludlow.
Wood's fiction is characterized by intricate plotting, domestic drama, and vivid depictions of Victorian middle-class life. Although her literary reputation declined after her death, East Lynne endures as a landmark of the Victorian sensation novel genre.