Meade's most celebrated work, A World of Girls (1886), is regarded as a landmark in school-story literature, helping to establish a genre later developed by authors such as Angela Brazil. Other popular girls' novels include The Palace Beautiful (1887) and A Sweet Girl Graduate (1891).
Beyond juvenile fiction, Meade pioneered early detective fiction, frequently collaborating with Dr. Robert Eustace. Notable works include The Brotherhood of the Seven Kings (1899), featuring the brilliant female mastermind Madame Koluchy, and The Sorceress of the Strand (1903), which introduced the charming criminal Madame Sara. Many of these stories, first serialized in The Strand Magazine, were groundbreaking for their portrayal of intelligent female villains and scientific detection, securing Meade's lasting reputation as a forerunner of modern mystery writing.