His debut, The Benson Murder Case (1926), introduced Philo Vance, an erudite, aristocratic amateur sleuth whose sophisticated style and psychological insight captivated readers. Vance became a cultural phenomenon through a series of bestsellers, including The Canary Murder Case (1927), The Greene Murder Case (1928), The Bishop Murder Case (1929)—often regarded as his masterpiece—and The Kennel Murder Case (1933). Many of these novels were adapted into successful Hollywood films.
Beyond fiction, Van Dine authored "Twenty Rules for Writing Detective Stories" (1928), a seminal essay defining fair-play conventions that shaped the entire mystery genre. His ingenious puzzle plots and refined detective left an enduring legacy on crime literature worldwide.