Uncle Tom's Cabin became an immediate sensation, selling hundreds of thousands of copies and profoundly influencing public opinion on slavery in the years preceding the Civil War. President Abraham Lincoln reportedly greeted her as "the little woman who wrote the book that started this great war." She followed it with A Key to Uncle Tom's Cabin (1853), defending her portrayal of slavery, and Dred: A Tale of the Great Dismal Swamp (1856), another anti-slavery novel.
Beyond abolitionist literature, Stowe wrote domestic fiction and regional novels, including The Minister's Wooing (1859), The Pearl of Orr's Island (1862), and Oldtown Folks (1869). Her works combined vivid storytelling with strong moral purpose, securing her place as one of the most influential American writers of the nineteenth century.