Settling in London, Smollett achieved immediate success with his first novel, The Adventures of Roderick Random (1748), a semi-autobiographical tale drawing on his naval service. He followed it with The Adventures of Peregrine Pickle (1751), The Adventures of Ferdinand Count Fathom (1753), and The Life and Adventures of Sir Launcelot Greaves (1760). A prolific man of letters, he founded and edited The Critical Review, translated Cervantes's Don Quixote and Le Sage's Gil Blas, and produced histories and travel writing, including Travels through France and Italy (1766).
His masterpiece, The Expedition of Humphry Clinker (1771), an epistolary comic novel, is admired for its warmth, rich characterization, and humor. Smollett died near Leghorn, Italy, in 1771, leaving a lasting influence on the English novel and later writers such as Dickens.