Sterne's fame rests chiefly on his masterpiece, The Life and Opinions of Tristram Shandy, Gentleman, published in nine volumes between 1759 and 1767. The novel astonished contemporary readers with its eccentric structure, endless digressions, typographical playfulness, blank and marbled pages, and self-conscious humor. Today it is regarded as a precursor of modernist and postmodernist fiction, admired by writers from Goethe to Virginia Woolf.
In 1768, while gravely ill with tuberculosis, Sterne published A Sentimental Journey Through France and Italy, a shorter travel narrative that helped establish the "sentimental novel" as a genre, emphasizing emotion and sympathy over plot. He also produced several volumes of sermons under the title The Sermons of Mr. Yorick. Sterne died in London in 1768, leaving a lasting legacy as a pioneer of literary experimentation and comic genius.