Wolfe's writing is distinguished by its emotional intensity, rich imagery, and passionate exploration of youth, memory, and the American experience. His second major novel, Of Time and the River (1935), continued Eugene Gant's journey through young adulthood. After Wolfe's early death from tuberculosis at age thirty-seven, two further novels were published posthumously: The Web and the Rock (1939) and You Can't Go Home Again (1940), whose title became a famous phrase expressing the impossibility of returning to the past.
Working closely with legendary editor Maxwell Perkins, Wolfe produced a body of work noted for its vast scope and poetic language. Though critics debated his stylistic excesses, he is widely regarded as one of the most significant American novelists of the twentieth century, influencing writers such as Jack Kerouac, Ray Bradbury, and Hunter S. Thompson.