Perry achieved her greatest success with the Resident Evil series, a seven-volume companion to Capcom's acclaimed survival-horror games, published between 1998 and 2004. Titles such as The Umbrella Conspiracy, City of the Damned, Nemesis, and Code: Veronica were praised for deepening the games' atmosphere and characters, and the series remains beloved by franchise fans.
She is also a notable contributor to the Star Trek universe, having written the Deep Space Nine relaunch duology Avatar (2001), the Gateways novel Demons of Air and Darkness (2001), Rising Son (2003), and Section 31: Cloak (2004). Throughout her career, Perry has been recognized for her faithful yet imaginative expansion of established fictional worlds, blending action, horror, and strong characterization in her storytelling.